With the continuous development of enterprise marketing, the enterprise abbreviation has been widely used. Nevertheless, as one of the main sources of unknown words, the enterprise abbreviation can not be effectively identified. A methodology on predicting enterprise abbreviation based on constitution pattern and Conditional Random Field (CRF) was proposed. First, the constitution patterns of enterprise name and abbreviation were summarized from the perspective of linguistics, and the Bi-gram algorithm was improved by a combination of lexicon and rules, namely CBi-gram. CBi-gram algorithm was used to realize the automatic segmentation of the enterprise name and improve the recognition accuracy of the company's core word. Then the enterprise type was subdivided by CBi-gram, and the abbreviation rule sets were collected by artificial summary and self-learning method to reduce noise caused by unsuitable rules. Besides, in order to make up the limitations of artificial building rules on abbreviations and mixed abbreviation, the CRF was introduced to generate enterprise abbreviation statistically, and word, tone and word position were used as characteristics to train model as supplementary. The experimental results show that the method exhibites a good performance and the output can fundamentally cover the usual range of enterprise abbreviations.